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Article

A potential novel mechanism for precocious puberty in juvenile hypothyroidism.

1 Jan 1995

Abstract excerpt

Some children with juvenile hypothyroidism exhibit unexplained precocious puberty. Interaction of TSH with the human FSH receptor (hFSH-R) is a possible pathophysiological mechanism for this syndrome that has not been explored due to the lack of hFSH-free TSH preparations and the scarcity of a suitable hFSH-R-based assay system. To devise an in vitro FSH bioassay suitable for exploring this mechanism, we...

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PMID: 7829625
DOI: 10.1210/jcem.80.1.7829625

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