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Article

Generation and characterization of a hypothyroidism rat model with truncated thyroid stimulating hormone receptor.

Scientific reports - 5 Mar 2018

Yang Jianqiang, Yi Ning, Zhang Junhui, He Wen, He Di, Wu Wanwan, Xu Shuyang, Li Feng, Fan Guoping, Zhu Xianmin, Xue Zhigang, Zhou Wensheng

Abstract excerpt

Thyroid stimulating hormone receptor (TSHR), a G-protein-coupled receptor, is important for thyroid development and growth. In several cases, frameshift and/or nonsense mutations in TSHR were found in the patients with congenital hypothyroidism (CH), however they have not been functionally studied in an animal model. In the present work, we generated a unique Tshr Df/Df rat model that recapitulates the phenotypes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29507327
DOI: 10.1038/s41598-018-22405-7
PMCID: PMC5838214

Genes

TSHR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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