Article
Evaluating the roles of follicle-stimulating hormone receptor polymorphisms in gonadal hyperstimulation associated with severe juvenile primary hypothyroidism.
The Journal of clinical endocrinology and metabolism - 1 Jun 2007
Ryan Ginny L, Feng Xiuyan, d'Alva Catarina Brasil, Zhang Meilin, Van Voorhis Bradley J, Pinto Emilia Modolo, Kubias Ana Elisa F, Antonini Sonir R, Latronico Ana Claudia, Segaloff Deborah L
Abstract excerpt
CONTEXT: Rare activating mutations of the human (h)FSHR have been reported in some women with spontaneous ovarian hyperstimulation in pregnancy, where follicular growth is inappropriately stimulated by elevated concentrations of human chorionic gonadotropin acting through the hFSHR. It is not known whether ovarian hyperstimulation in peripubertal girls with untreated primary hypothyroidism is caused by hFSHR...
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