Origin and impact of plasmid-mediated extended-spectrum beta-lactamases.

doi:10.1007/BF02390681

Article

Origin and impact of plasmid-mediated extended-spectrum beta-lactamases.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Jan 1994

Philippon A, Arlet G, Lagrange P H

Abstract excerpt

Resistance to oxyimino cephalosporins was originally highlighted by the emergence of plasmid-encoded extended-spectrum beta-lactamases deriving by mutation from TEM-1, TEM-2 and SHV type enzymes (class A). The broader spectrum of resistance produced by these enzymes is related to more amino acid...

Topics

Clavulanic Acids
Gram-Negative Bacteria
Klebsiella pneumoniae
Mutation
Plasmids
beta-Lactam Resistance
beta-Lactamases

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.