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Article

Origin and impact of plasmid-mediated extended-spectrum beta-lactamases.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Jan 1994

Philippon A, Arlet G, Lagrange P H

Abstract excerpt

Resistance to oxyimino cephalosporins was originally highlighted by the emergence of plasmid-encoded extended-spectrum beta-lactamases deriving by mutation from TEM-1, TEM-2 and SHV type enzymes (class A). The broader spectrum of resistance produced by these enzymes is related to more amino acid substitutions, but susceptibility to seven alpha-methoxyimino cephalosporins and carbapenems was preserved until...

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PMID: 7821300
DOI: 10.1007/BF02390681

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