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Article

Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated beta-lactamase with two molecular variants.

Antimicrobial agents and chemotherapy - 1 Sept 1994

Gonzalez Leiza M, Perez-Diaz J C, Ayala J, Casellas J M, Martinez-Beltran J, Bush K, Baquero F

Abstract excerpt

Klebsiella pneumoniae BA32, a clinical isolate from Buenos Aires, Argentina, was found to produce a plasmid-encoded beta-lactamase (FOX-1) which conferred resistance to broad-spectrum cephalosporins and cephamycins. Resistance could be transferred by conjugation or transformation into Escherichia coli K-12 via a 48.5-kb plasmid (pGLK1) that produced two FOX-1 molecular variants with isoelectric points of 6.8 and...

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Identifiers

PMID: 7811034
DOI: 10.1128/AAC.38.9.2150
PMCID: PMC284699

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