Article
Late-onset mitochondrial myopathy.
Annals of neurology - 1 Jan 1995
Johnston W, Karpati G, Carpenter S, Arnold D, Shoubridge E A
Abstract excerpt
In the majority of patients with mitochondrial encephalomyopathies, signs and symptoms appear in the first three decades of life. Here we report on a group of 9 older patients (> 69 years old) with late-onset skeletal myopathy characterized by focal accumulations of deleted mitochondrial DNAs (mtDNAs) and altered muscle energy status, suggestive of a primary mitochondrial disease. The clinical phenotype was...
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