Article
Mitochondrial DNA mutation and muscle pathology in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes.
Muscle & nerve. Supplement - 1 Jan 1995
Mita S, Tokunaga M, Kumamoto T, Uchino M, Nonaka I, Ando M
Abstract excerpt
We sought a relationship between abnormalities of mitochondrial DNA (mtDNA) and muscle pathology in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes (MELAS) at the single fiber level, using histochemistry, in situ hybridization, and single fiber PCR. Most type 1 ragged-red fibers (RRF) showed positive cytochrome c oxidase (COX) activity at the subsarcolemmal region,...
Topics
- Arteries
- Base Sequence
- Cerebrovascular Disorders
- DNA, Mitochondrial
- Electron Transport Complex IV
- Humans
- MERRF Syndrome
- Molecular Sequence Data
- Muscles
- Mutation
- Succinate Dehydrogenase