Article
[Myoglobinuria caused by multiple deletions of mitochondrial DNA].
Rinsho byori. The Japanese journal of clinical pathology - 1 Feb 1991
Tanaka M, Ohno K, Sahashi K, Ibi T, Tashiro M, Ino H, Takahashi A, Ozawa T
Abstract excerpt
We report two brothers with inherited recurrent myoglobinuria associated with distinct morphological abnormalities of muscle mitochondria and multiple deletions of muscle mitochondrial DNA. Patient 1 (26 years old) and Patient 2 (21 years old) had recurrent episodes of myoglobinuria provoked by strenuous exercise or alcohol intake. Histochemistry of their biopsied limb muscles showed ragged-red fibers and...
Topics
- Base Sequence
- Chromosome Deletion
- DNA, Mitochondrial
- Microscopy, Electron
- Mitochondria, Muscle
- Molecular Sequence Data
- Muscles
- Mutation
- Myoglobinuria
- Polymerase Chain Reaction
- Recurrence