Article
Evolution of base composition in the insulin and insulin-like growth factor genes.
Molecular biology and evolution - 1 Nov 1994
Ellsworth D L, Hewett-Emmett D, Li W H
Abstract excerpt
The genomes of homeothermic (warm-blooded) vertebrates are mosaic interspersions of homogeneously GC-rich and GC-poor regions (isochores). Evolution of genome compartmentalization and GC-rich isochores is hypothesized to reflect either selective advantages of an elevated GC content or chromosome location and mutational pressure associated with the timing of DNA replication in germ cells. To address the present...
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