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Article

Chemiluminescent detection of blotted PCR products (CB-PCR) of two CAG dynamic mutations (Huntington's disease and spinocerebellar ataxia type 1).

Journal of medical genetics - 1 Aug 1994

Castellví-Bel S, Matilla T, Banchs M I, Kruyer H, Corral J, Milà M, Estivill X

Abstract excerpt

We have used a non-isotopic PCR assay based on the chemiluminescent detection of blotted PCR products (CB-PCR) for two dynamic mutation diseases (Huntington's disease and spinocerebellar ataxia type 1). This gives an accurate sizing of alleles and permits a rapid analysis of at risk persons. The system involves PCR of the samples, separation of alleles on polyacrylamide gels, Southern blotting, and hybridisation...

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Identifiers

PMID: 7815428
DOI: 10.1136/jmg.31.8.654
PMCID: PMC1050033

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Source receipt: pubmed, retrieved 7 Sept 2026.

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