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Article

Nonisotopic method for accurate detection of (CAG)n repeats causing Huntington disease.

Clinical chemistry - 1 Oct 1996

Muglia M, Leone O, Annesi G, Gabriele A L, Imbrogno E, Grandinetti C, Conforti F L, Naso F, Brancati C

Abstract excerpt

Huntington disease (HD) is a neurodegenerative disorder caused by an expanded trinucleotide repeat (CAG)n located at the 5' end of the novel IT15 gene. Discovery of this expansion allows the molecular diagnosis of HD by measuring repeat length. We applied a simple nonisotopic method to detect (CA...

Topics

Alleles
DNA Primers
Humans
Huntingtin Protein
Huntington Disease
Mutation
Nerve Tissue Proteins
Nuclear Proteins
Polymerase Chain Reaction
Proteins
Repetitive Sequences, Nucleic Acid
Silver Nitrate

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PMID: 8855141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8855141-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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