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Article

Nonisotopic method for accurate detection of (CAG)n repeats causing Huntington disease.

Clinical chemistry - 1 Oct 1996

Muglia M, Leone O, Annesi G, Gabriele A L, Imbrogno E, Grandinetti C, Conforti F L, Naso F, Brancati C

Abstract excerpt

Huntington disease (HD) is a neurodegenerative disorder caused by an expanded trinucleotide repeat (CAG)n located at the 5' end of the novel IT15 gene. Discovery of this expansion allows the molecular diagnosis of HD by measuring repeat length. We applied a simple nonisotopic method to detect (CAG)n repeats, avoiding both radioactive and Southern transfer analysis. The assay is based on direct visualization of...

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PMID: 8855141

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