Article
Structural and functional consequences of an N-glycosylation mutation (HEMPAS) affecting human erythrocyte membrane glycoproteins.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jan 1998
Kameh H, Landolt-Marticorena C, Charuk J H, Schachter H, Reithmeier R A
Abstract excerpt
Band 3, the human erythrocyte anion exchanger (AE1), and the glucose transporter (GLUT1) proteins each contain a single site of N-glycosylation that is heterogeneously glycosylated. Lectin binding and enzymatic deglycosylation assays showed that the polylactosaminyl oligosaccharide structure of these glycoproteins was altered to a high mannose or hybrid glycan form in three patients with hereditary erythroblastic...
Topics
- Anemia, Dyserythropoietic, Congenital
- Anion Exchange Protein 1, Erythrocyte
- Cell Line, Transformed
- Cytoskeleton
- Erythrocytes
- Glycosylation
- Humans
- Lectins
- Membrane Glycoproteins
- Models, Biological