Article
Segregation analysis of smoking-associated malignancies: evidence for Mendelian inheritance.
American journal of medical genetics - 1 Sept 1994
Sellers T A, Chen P L, Potter J D, Bailey-Wilson J E, Rothschild H, Elston R C
Abstract excerpt
Tobacco consumption is an established risk factor for cancer at a number of sites: oral cavity, esophagus, nasopharynx, lung, larynx, pancreas, bladder, kidney, and uterine cervix. These sites also demonstrate familial aggregation. To determine if evidence exists for a major gene controlling susceptibility to smoking-associated cancers, maximum likelihood segregation analyses were performed on 337 families (3,276...
Topics
- Environment
- Female
- Genes, Dominant
- Genes, Recessive
- Humans
- Likelihood Functions
- Lung Neoplasms
- Male
- Models, Genetic
- Neoplasms
- Phenotype
- Risk Factors