Retinoblastoma: Review and new insights

doi:10.3389/fonc.2022.963780

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Retinoblastoma: Review and new insights

2 Nov 2022

Abstract excerpt

Retinoblastoma (Rb), the most frequent malignant intraocular tumor in childhood, is caused by mutations in the retinoblastoma gene ( RB1 ) situated on chromosome 13q14.2. The incidence of retinoblastoma is approximately 1 in 17,000 live births with approximately 8,000 new cases diagnosed each year worldwide. Rb is the prototypical hereditary cancer in humans. Autosomal dominant inheritance is seen in 30-40% of...

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PMID: 36408154
DOI: 10.3389/fonc.2022.963780

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