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Article

Protective and nonprotective monoclonal antibodies to Cryptococcus neoformans originating from one B cell.

The Journal of experimental medicine - 1 Jan 1995

Mukherjee J, Nussbaum G, Scharff M D, Casadevall A

Abstract excerpt

Two immunoglobulin M monoclonal antibodies (mAbs) derived from the same B cell recognize different epitopes on the capsular polysaccharide of the pathogenic yeast, Cryptococcus neoformans. Their respective epitopes are located in spatially distinct regions of the capsule. Passive administration of one mAb prolonged survival whereas the other mAb did not. The results indicate that specificity is an important...

Topics

Amino Acid Sequence
Animals
Antibodies, Fungal
Antibodies, Monoclonal
Antibody Affinity
Antibody Diversity
B-Lymphocytes
Clone Cells
Cryptococcosis
Cryptococcus neoformans
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred A

Molecular Sequence Data

Mutation

Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 7807020
DOI: 10.1084/jem.181.1.405
PMCID: PMC2191853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7807020-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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