Article
Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis: FnBPA is sufficient to activate human endothelial cells.
Thrombosis and haemostasis - 1 Apr 2007
Heying Ruth, van de Gevel Joke, Que Yok-Ai, Moreillon Philippe, Beekhuizen Henry
Abstract excerpt
Surface molecules of Staphylococcus aureus are involved in the colonization of vascular endothelium which is a crucial primary event in the pathogenesis of infective endocarditis (IE). The ability of these molecules to also launch endothelial procoagulant and proinflammatory responses, which characterize IE, is not known. In the present study we investigated the individual capacities of three prominent S. aureus...
Topics
- Adhesins, Bacterial
- Bacterial Adhesion
- Blood Coagulation
- Cell Adhesion
- Cells, Cultured
- Coagulase
- Endocarditis, Bacterial
- Endothelial Cells
- Humans
- Intercellular Adhesion Molecule-1
- Interleukin-8
- Lactococcus lactis
- Monocytes