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Article

Functional human epidermal Langerhans cells that lack Birbeck granules.

The Journal of investigative dermatology - 1 Dec 1994

Mommaas M, Mulder A, Vermeer B J, Koning F

Abstract excerpt

Birbeck granules (BG) are cytoplasmic organelles that are only found in Langerhans cells (LC). The function of BG is still unclear, although it has been claimed that they are actively involved in receptor-mediated endocytosis and participate in the antigen-processing/presenting function of LC. We have identified a healthy white 29-year-old man whose LC completely lack the presence of BG as determined by...

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Identifiers

PMID: 7798619
DOI: 10.1111/1523-1747.ep12413456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional human epidermal Langerhans cells that lack Birbeck granules.PMID 7798619Read ↗

Dynamic nature and function of epidermal Langerhans cells in vivo and in vitro: a review, with emphasis on human Langerhans cells.Semantic proximity Read ↗

Human epidermal Langerhans cells undergo profound morphologic and phenotypical changes during in vitro culture.Semantic proximity Read ↗

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The normal Langerhans cell and the LCH cell.Semantic proximity Read ↗

In vitro analysis of the phenotypical and functional properties of the 4F7+ cutaneous accessory dendritic cell.Semantic proximity Read ↗

Birbeck granule-like "organized smooth endoplasmic reticulum" resulting from the expression of a cytoplasmic YFP-tagged langerin.Semantic proximity Read ↗

A Lack of Birbeck Granules in Langerhans Cells Is Associated with a Naturally Occurring Point Mutation in the Human Langerin GeneSemantic proximity Read ↗

Immunophenotypic characterization of feline Langerhans cells.Semantic proximity Read ↗

Purification of functional active epidermal Langerhans cells: a simple and efficient new technique.Semantic proximity Read ↗

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