Article
Experimental human gonococcal urethritis: 250 Neisseria gonorrhoeae MS11mkC are infective.
The Journal of infectious diseases - 1 Jul 1995
Schneider H, Cross A S, Kuschner R A, Taylor D N, Sadoff J C, Boslego J W, Deal C D
Abstract excerpt
Neisseria gonorrhoeae MS11mkA (mkA) expresses one 3.6-kDa lipooligosaccharide (LOS). Variant MS11mkC (mkC), expressing four larger LOSs, occurs in vitro among mkA at a frequency of 10(-3). Infectivity of these variants was compared in 2 groups of volunteers inoculated with approximately 40,000 piliated, Opa- gonococci of either strain. The mkC variant infected 5 of 5 while mkA infected only 2 (40%) of 5....
Topics
- Adolescent
- Adult
- Antibodies, Monoclonal
- Antigens, Bacterial
- Genetic Variation
- Gonorrhea
- Humans
- Lipopolysaccharides
- Male
- Middle Aged
- Neisseria gonorrhoeae