Differential sensitivity to transforming growth factor (TGF)-beta of CBA and of CBA/N B cells demonstrates that the IgG2b inducing factor in synovial fluid from rheumatoid arthritis patients is not identical to TGF-beta.

doi:10.1093/intimm/7.3.459

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Article

Differential sensitivity to transforming growth factor (TGF)-beta of CBA and of CBA/N B cells demonstrates that the IgG2b inducing factor in synovial fluid from rheumatoid arthritis patients is not identical to TGF-beta.

International immunology - 1 Mar 1995

Ridderstad A, Lettesjö H, Abedi-Valugerdi M, Möller E

Abstract excerpt

Synovial fluid from patients with rheumatoid arthritis (RA-SF) contains in vivo produced cytokines and inflammatory mediators, including a factor that induces IgG2b production of lipopolysaccharide (LPS) preactivated murine B lymphocytes. In order to determine the mechanism by which RA-SF acts on LPS activated mouse B cells, CBA/N mice were used as an experimental model. The X-linked immunodeficiency of these...

Topics

Agammaglobulinaemia Tyrosine Kinase
Alleles
Animals
Arthritis, Rheumatoid
B-Lymphocytes
Base Sequence
Biological Factors
DNA Mutational Analysis
Female
Immunoglobulin G

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunologic Deficiency Syndromes

Interleukin-4

Lipopolysaccharides

Lymphocyte Activation

Male

Mice

Mice, Inbred CBA

Mice, Mutant Strains

Source

Open in PubMed

Identifiers

PMID: 7794824
DOI: 10.1093/intimm/7.3.459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7794824-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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