Article
[Oncogenes and cancer of the larynx. EGFR, p21 ras and HPV-DNA infections].
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale - 1 Feb 1995
Almadori G, Cadoni G, Maurizi M, Ottaviani F, Paludetti G, Cattani P, Scambia G
Abstract excerpt
The modern concept of oncogenesis is based upon the interaction between factors which modulate cellular growth and differentiation, in particular oncogenes and tumor suppressor genes. The molecular events which induce laryngeal carcinogenesis are not yet known. Protoncogenes seem to be the target of the risk factors (cigarette smoking, alcohol abuse, ionizing radiations and, not least HPV-DNA) that are commonly...
Topics
- Adult
- Aged
- Blotting, Western
- Carcinoma, Squamous Cell
- DNA, Viral
- ErbB Receptors
- Female
- Gene Amplification
- Gene Expression
- Genes, Tumor Suppressor
- Genes, p53
