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Article

Genome-wide analyses reveal a highly conserved Dengue virus envelope peptide which is critical for virus viability and antigenic in humans.

Scientific reports - 2 Nov 2016

Fleith Renata C, Lobo Francisco P, Dos Santos Paula F, Rocha Mariana M, Bordignon Juliano, Strottmann Daisy M, Patricio Daniel O, Pavanelli Wander R, Lo Sarzi Maria, Santos Claudia N D, Ferguson Brian J, Mansur Daniel S

Abstract excerpt

Targeting regions of proteins that show a high degree of structural conservation has been proposed as a method of developing immunotherapies and vaccines that may bypass the wide genetic variability of RNA viruses. Despite several attempts, a vaccine that protects evenly against the four circulating Dengue virus (DV) serotypes remains elusive. To find critical conserved amino acids in dengue viruses, 120 complete...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27805018
DOI: 10.1038/srep36339
PMCID: PMC5090869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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