Article
Factor V Leiden gene mutation and thrombin generation in relation to the development of acute stroke.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 1995
Catto A, Carter A, Ireland H, Bayston T A, Philippou H, Barrett J, Lane D A, Grant P J
Abstract excerpt
To determine the prevalence of the factor V Leiden gene mutation in relation to the phenotypes of cerebral infarction and cerebral hemorrhage, we studied 386 randomly selected cases of acute stroke and 247 control subjects. Factor V genotype was determined by amplification of a 267-bp sequence of exon/intron 10 of the factor V gene. Levels of prothrombin fragment F(1 + 2), a marker of thrombin generation, were...
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