Article
Antigenic Variation by Positional Control of Major Surface Glycoprotein Gene Expression in Pneumocystis carinii
1 Jun 1995
Abstract excerpt
Major cell surface glycoproteins (MSGs) of Pneumocystis carinii play a crucial role in host-parasite interactions during P. carinii pneumocystosis in AIDS patients. Genes encoding MSGs are repeated and dispersed throughout the genome and are highly polymorphic. MSG gene expression was found to be mediated by a DNA element that was termed the upstream conserved sequence (UCS). The UCS element maps to a single...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
