The major role of Spo0A in genetic competence is to downregulate abrB, an essential competence gene.

doi:10.1128/jb.177.12.3601-3605.1995

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Article

The major role of Spo0A in genetic competence is to downregulate abrB, an essential competence gene.

Journal of bacteriology - 1 Jun 1995

Hahn J, Roggiani M, Dubnau D

Abstract excerpt

We show that the major role for Spo0A in the development of genetic competence is to downregulate expression of abrB. AbrB is both a negative regulator and a positive regulator of competence. The negative effects are exerted at multiple points in competence regulation. A regulatory mechanism that...

Topics

Bacillus subtilis
Bacterial Proteins
Base Sequence
Cloning, Molecular
DNA-Binding Proteins
Down-Regulation
Gene Expression Regulation, Bacterial
Molecular Sequence Data
Mutation
Transcription Factors
Transformation, Bacterial

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