Article
Stereoselective disposition of carvedilol is determined by CYP2D6.
Clinical pharmacology and therapeutics - 1 May 1995
Zhou H H, Wood A J
Abstract excerpt
Carvedilol is a mixed alpha- and beta-adrenergic receptor antagonist that is administered as a racemic mixture. Although the two isomers are equally potent as alpha 1-blockers the S(-)-isomer is principally responsible for the beta blockade of carvedilol. To determine the role of pharmacogenetics...
Topics
- Adrenergic alpha-Antagonists
- Adrenergic beta-Antagonists
- Adult
- Carbazoles
- Carvedilol
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Half-Life
- Humans
- Mephenytoin
- Metabolic Clearance Rate