Metabolism of citalopram enantiomers in CYP2C19/CYP2D6 phenotyped panels of healthy Swedes.

doi:10.1046/j.1365-2125.2003.01874.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Metabolism of citalopram enantiomers in CYP2C19/CYP2D6 phenotyped panels of healthy Swedes.

British journal of clinical pharmacology - 1 Oct 2003

Herrlin Karin, Yasui-Furukori Norio, Tybring Gunnel, Widén Jolanta, Gustafsson Lars L, Bertilsson Leif

Abstract excerpt

AIMS: To investigate pharmacokinetics of the enantiomers of citalopram (CT) and its metabolites desmethylcitalopram (DCT) and didesmethylcitalopram (DDCT) in Swedish healthy volunteers in relation to CYP2C19 and CYP2D6 geno- and phenotypes. METHODS: Racemic CT was given for seven days to panels with different genotypes and the following mephenytoin (Me) and debrisoquine (De) hydroxylation phenotypes: EMDe/EMMe,...

Topics

Adult
Antidepressive Agents
Area Under Curve
Aryl Hydrocarbon Hydroxylases
Citalopram
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2D6
Female
Genotype
Humans
Isomerism
Male
Mixed Function Oxygenases
Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 12968986
DOI: 10.1046/j.1365-2125.2003.01874.x
PMCID: PMC1884377

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics