Article
Atypical Gly-X-Y sequences surround interruptions in the repeating tripeptide pattern of basement membrane collagen.
Biopolymers - 1 Jun 1995
Long C G, Thomas M, Brodsky B
Abstract excerpt
The triple-helical domains of type IV collagen chains have more than 20 sites at which the repeating (Gly-X-Y)n pattern is interrupted. Analysis of alpha 1 (IV) and alpha 2 (IV) chains indicates the residues in the three Gly-X-Y triplets preceding or following interruptions differ statistically from the rest of the chain. Unusually high frequencies of charged residues are seen at a number of X and Y sites, with...
Topics
- Animals
- Basement Membrane
- Collagen
- Genetic Variation
- Humans
- Mice
- Oligopeptides
- Point Mutation
- Protein Conformation
- Sequence Deletion