Evidence for two-site binding of troponin I inhibitory peptides to the N and C domains of troponin C.

doi:10.1021/bi00021a004

Back to search

Article

Evidence for two-site binding of troponin I inhibitory peptides to the N and C domains of troponin C.

Biochemistry - 30 May 1995

Pearlstone J R, Smillie L B

Abstract excerpt

The interactions of two troponin I peptides, Ip1 (residues 96-116) and Ip2 (residues 104-116), with spectral probe mutants F29W and F105W of intact troponin C (TnC) and of isolated N (residues 1-90) and C (residues 88-162) domains of TnC have been examined. Ip-induced fluorescence emission spectr...

Topics

Animals
Calcium
Chromatography, Affinity
Mutation
Peptides
Protein Binding
Rabbits
Spectrometry, Fluorescence
Troponin
Troponin C
Troponin I

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.