Overproduction of riboflavin by an Arthrobacter sp. mutant resistant to 5-fluorouracil.

doi:10.1016/0141-0229(93)90101-7

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Article

Overproduction of riboflavin by an Arthrobacter sp. mutant resistant to 5-fluorouracil.

Enzyme and microbial technology - 1 Oct 1993

Yamane Y, Ooshima H, Kato J

Abstract excerpt

Antagonistic action between 5-fluorouracil (5-FU) and riboflavin (RF) was investigated. The growth of Arthrobacter sp. was inhibited by 5-FU at 5 x 10(-5) M, and the inhibition was reversed by RF at 5 x 10(-5) M. 5-FU-resistant mutants of Arthrobacter sp. were isolated and excreted RF in relative...

Topics

Arthrobacter
Biotechnology
Cell Division
Detergents
Drug Resistance, Microbial
Fermentation
Fluorouracil
Kinetics
Mutation
Purines
Pyrimidines
Riboflavin
Zinc

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