Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Implication of Ref-1 in the repression of renin gene transcription by intracellular calcium

1 Feb 2003

Abstract excerpt

OBJECTIVE: The production of renin, which catalyzes the rate-limiting step of the renin-angiotensin system, is tightly regulated by intracellular second messengers. Among them, an increase of intracellular calcium represses renin gene expression. This inhibition of gene expression by intracellular calcium is exceptional, and the molecular mechanism supporting this phenomenon has not yet been identified. As the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Renin-Angiotensin System Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12569263
DOI: 10.1097/00004872-200302000-00024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Implication of Ref-1 in the repression of renin gene transcription by intracellular calciumPMID 12569263Read ↗

Transcriptional Regulation of ReninSemantic proximity Read ↗

A Novel Signal Transduction Cascade Involving Direct Physical Interaction of the Renin/Prorenin Receptor With the Transcription Factor Promyelocytic Zinc Finger ProteinSemantic proximity Read ↗

Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression.Semantic proximity Read ↗

Regulation of apoA1 gene expression with acidosis: requirement for a transcriptional repressor.Semantic proximity Read ↗

cis-regulatory elements and trans-acting factors directing basal and cAMP-stimulated human renin gene expression in chorionic cells.Semantic proximity Read ↗

Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter.Semantic proximity Read ↗

Cytoplasmic localization and redox cysteine residue of APE1/Ref-1 are associated with its anti-inflammatory activity in cultured endothelial cells.Semantic proximity Read ↗

Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for HomeostasisSemantic proximity Read ↗

Expression and regulation of the atrial natriuretic factor encoding gene during development and diseaseSemantic proximity Read ↗

[Regulation of parathyroid hormone in molecular biological aspect].Semantic proximity Read ↗

In vivo analysis of key elements within the renin regulatory region.Semantic proximity Read ↗

The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.