E-cadherin as a tumor (invasion) suppressor gene.

doi:10.1002/bies.950170203

Back to search

Article

E-cadherin as a tumor (invasion) suppressor gene.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Feb 1995

Birchmeier W

Abstract excerpt

Diffuse-type gastric carcinomas show diminished cell-cell adhesion. A recent paper reports that 50% of these carcinomas contain mutations in the E-cadherin gene, resulting in the destruction of the calcium-binding sites of E-cadherin, and providing strong in vivo evidence that alterations in E-ca...

Topics

Adenomatous Polyposis Coli Protein
Antigens, CD
Cadherins
Cell Adhesion Molecules
Cytoskeletal Proteins
Genes, Tumor Suppressor
Humans
Mutation
Stomach Neoplasms

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.