Article
Analysis of transitions at two-fold redundant sites in mammalian genomes. Transition redundant approach-to-equilibrium (TREx) distance metrics.
BMC evolutionary biology - 20 Mar 2006
Li Tang, Chamberlin Stephen G, Caraco M Daniel, Liberles David A, Gaucher Eric A, Benner Steven A
Abstract excerpt
BACKGROUND: The exchange of nucleotides at synonymous sites in a gene encoding a protein is believed to have little impact on the fitness of a host organism. This should be especially true for synonymous transitions, where a pyrimidine nucleotide is replaced by another pyrimidine, or a purine is replaced by another purine. This suggests that transition redundant exchange (TREx) processes at the third position of...
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