Article
Identical HLA class II alleles predispose to drug-triggered and idiopathic pemphigus vulgaris.
Acta dermato-venereologica - 1 Jan 1995
Matzner Y, Erlich H A, Brautbar C, Sanilevitch A, Landau M, Brenner S, Friedmann A
Abstract excerpt
In pemphigus vulgaris, a dermatological autoimmune disease, specific human leukocyte antigen (HLA) class II alleles, DR4 (DRB1*0402) and DRw14 (DRB1*1401, in linkage disequilibrium with DQB1*0503), are thought to be susceptibility genes involved in the onset of the disease. We studied the HLA class II alleles (DQA1, DQB1, DRB1 and DPB1) of 6 patients with pemphigus, in whom the disease was "triggered" by drugs...
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