Article
Study of the association between human leukocyte antigens (HLA) and pemphigus vulgaris in Brazilian patients.
International journal of dermatology - 1 May 2017
Gil Julio M, Weber Raimar, Rosales Claudia B, Rodrigues Helcio, Sennes Luiz U, Kalil Jorge, Chagury Azis, Miziara Ivan D
Abstract excerpt
BACKGROUND: Pemphigus vulgaris is a mucocutaneous blistering autoimmune disease that manifests as painful blisters or erosions on the skin and/or mucosal surfaces. IgG autoantibodies target desmoglein, playing a major role in disease pathogenesis. Genetic predisposal to pemphigus vulgaris, especially the HLA DR and DQ alleles, has been known since the 1980s. The unique constitution of the Brazilian population...
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