Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Vif accessory protein alters the cell cycle of human immunodeficiency virus type 1 infected cells.

Virology - 15 Mar 2007

Wang Jiangfang, Shackelford Jason M, Casella Carolyn R, Shivers Debra K, Rapaport Eric L, Liu Bindong, Yu Xiao-Fang, Finkel Terri H

Abstract excerpt

The viral infectivity factor gene (vif) of HIV-1 increases the infectivity of viral particles by inactivation of cellular anti-viral factors, and supports productive viral replication in primary human CD4 T cells and in certain non-permissive T cell lines. Here, we demonstrate that Vif also contributes to the arrest of HIV-1 infected cells in the G(2) phase of the cell cycle. Viruses deleted in Vif or Vpr induce...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Products, vif

Share to Gene Products, vpr

Share to Jurkat Cells

Share to T-Lymphocytes

Share to vif Gene Products, Human Immunodeficiency Virus

Share to vpr Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 17056089
DOI: 10.1016/j.virol.2006.09.026
PMCID: PMC1934563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Vif accessory protein alters the cell cycle of human immunodeficiency virus type 1 infected cells.PMID 17056089Read ↗

Human Immunodeficiency Virus Type 1 Vif causes dysfunction of Cdk1 and CyclinB1: implications for cell cycle arrestSemantic proximity Read ↗

Human immunodeficiency virus type 1 Vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradation.Semantic proximity Read ↗

Dual Functionality of HIV-1 Vif in APOBEC3 Counteraction and Cell Cycle ArrestSemantic proximity Read ↗

Role of viral regulatory and accessory proteins in HIV-1 replicationSemantic proximity Read ↗

The Vif and Vpr accessory proteins independently cause HIV-1-induced T cell cytopathicity and cell cycle arrest.Semantic proximity Read ↗

Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T LymphocytesSemantic proximity Read ↗

Functional Analysis of Vif Protein Shows Less Restriction of Human Immunodeficiency Virus Type 2 by APOBEC3GSemantic proximity Read ↗

Comparative analyses of human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vif mutants.Semantic proximity Read ↗

Cell-dependent function of HIV-1 Vif for virus replication (Review).Semantic proximity Read ↗

Human immunodeficiency virus type 1 Vpr is a positive regulator of viral transcription and infectivity in primary human macrophages.Semantic proximity Read ↗

Cellular interactions of virion infectivity factor (Vif) as potential therapeutic targets: APOBEC3G and more?Semantic proximity Read ↗

The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycleSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.