Overexpression of TGF-beta 1 in the central nervous system of transgenic mice results in hydrocephalus.

doi:10.1097/00005072-199505000-00007

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Article

Overexpression of TGF-beta 1 in the central nervous system of transgenic mice results in hydrocephalus.

Journal of neuropathology and experimental neurology - 1 May 1995

Galbreath E, Kim S J, Park K, Brenner M, Messing A

Abstract excerpt

Transforming growth factor beta (TGF-beta) has been proposed to play a number of roles in central nervous system (CNS) development and response to injury. To test these proposals, transgenic mice were generated which overproduce TGF-beta 1 in the CNS. Surprisingly, these mice developed severe hyd...

Topics

Animals
Glial Fibrillary Acidic Protein
Hydrocephalus
Mice
Mice, Transgenic
Phenotype
RNA, Messenger
Transforming Growth Factor beta

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