Article
Prismatic cases: Laron syndrome (primary growth hormone resistance) from patient to laboratory to patient.
The Journal of clinical endocrinology and metabolism - 1 May 1995
Laron Z
Abstract excerpt
Clinical investigations started in 1958 of a group of children with characteristics resembling GH deficiency, but who had extremely high levels of plasma GH, led to the description of the syndrome of primary GH resistance or insensitivity (Laron syndrome), the discovery of its molecular defect, and the clinical application of biosynthetic insulin-like growth factor-I. This syndrome is a unique model that enables...
Topics
- Child, Preschool
- Drug Resistance
- Dwarfism
- Female
- Gene Deletion
- Growth Hormone
- Humans
- Infant
- Insulin-Like Growth Factor I
- Male
- Mutation
- Receptors, Somatotropin