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Article

The essential role of IGF-I: lessons from the long-term study and treatment of children and adults with Laron syndrome.

The Journal of clinical endocrinology and metabolism - 1 Dec 1999

Laron Z

Abstract excerpt

Fifty patients with primary GH resistance (Laron syndrome) due to molecular defects of the GH receptor or post-receptor pathways were followed from infancy through adulthood. This condition leading to long-term insulin-like growth factor-I (IGF-I) deprivation caused marked growth retardation (-4 to 8 height SD), acromicia, organomicria, retarded development of the skeletal and muscular systems, a small cranium,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10599694
DOI: 10.1210/jcem.84.12.6255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The essential role of IGF-I: lessons from the long-term study and treatment of children and adults with Laron syndrome.PMID 10599694Read ↗

Growth hormone insensitivity syndrome (Laron syndrome): main characteristics and effects of IGF1 treatment.Semantic proximity Read ↗

Insulin-like growth factor 1 (IGF-1): a growth hormoneSemantic proximity Read ↗

Disabilities and Handicaps of Patients with Laron SyndromeSemantic proximity Read ↗

IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome.Semantic proximity Read ↗

Phenotypes, investigation and treatment of primary IGF-1 deficiency.Semantic proximity Read ↗

Long-term IGF-I treatment of children with Laron syndrome increases adipositySemantic proximity Read ↗

Growth curves for Laron syndrome.Semantic proximity Read ↗

Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity?Semantic proximity Read ↗

Five year treatment with IGF-I of a patient with Laron syndrome in Slovenia (a follow-up report).Semantic proximity Read ↗

IGF-I in human growth: lessons from defects in the GH-IGF-I axis.Semantic proximity Read ↗

Laron syndrome - A historical perspective.Semantic proximity Read ↗

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