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Article

Characterization of a topoisomerase II gene rearrangement in a human small-cell lung cancer cell line.

Journal of the National Cancer Institute - 18 Nov 1992

Binaschi M, Giaccone G, Gazdar A F, De Isabella P, Ricotti G C, Capranico G, Zunino F

Abstract excerpt

BACKGROUND: Small-cell lung cancer (SCLC) is a highly chemosensitive tumor, but the recurrent disease that is common after initial response is often unresponsive to further chemotherapy. Although the mechanisms of drug resistance in SCLC have not been established, studies suggest that alterations of the nuclear enzyme DNA topoisomerase II may reduce the sensitivity of the cell to drug action. This enzyme is...

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Identifiers

PMID: 1331483
DOI: 10.1093/jnci/84.22.1710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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