Article
Characterization of a topoisomerase II gene rearrangement in a human small-cell lung cancer cell line.
Journal of the National Cancer Institute - 18 Nov 1992
Binaschi M, Giaccone G, Gazdar A F, De Isabella P, Ricotti G C, Capranico G, Zunino F
Abstract excerpt
BACKGROUND: Small-cell lung cancer (SCLC) is a highly chemosensitive tumor, but the recurrent disease that is common after initial response is often unresponsive to further chemotherapy. Although the mechanisms of drug resistance in SCLC have not been established, studies suggest that alterations of the nuclear enzyme DNA topoisomerase II may reduce the sensitivity of the cell to drug action. This enzyme is...
Topics
- Alleles
- Carcinoma, Small Cell
- DNA Topoisomerases, Type II
- DNA, Neoplasm
- Gene Expression
- Gene Rearrangement
- Humans
- Lung Neoplasms
- RNA, Messenger
- Restriction Mapping
- Tumor Cells, Cultured