Article
A coordinate upregulation of antioxidant gene activities is associated with the delayed onset of senescence in a long-lived strain of Drosophila.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 May 1995
Dudas S P, Arking R
Abstract excerpt
The extended longevity phenotype (ELP) characteristic of our selected long-lived strain of Drosophila is brought about by a delayed onset of senescence which occurs in the young (5-7 day) adult. Genetically competent animals will not express the resistance to exogenous paraquat characteristic of the ELP as adults unless they develop in a particular larval environment. This induction leads to a series of...
Topics
- Aging
- Animals
- Antioxidants
- Catalase
- Drosophila melanogaster
- Drug Resistance
- Gene Expression
- Glutathione Transferase
- Longevity
- Paraquat
- Phenotype