Genetic linkage in Pseudomonas aeruginosa of algT and nadB: mutation in nadB does not affect NAD biosynthesis or alginate production.

doi:10.1016/0378-1119(95)00028-5

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Article

Genetic linkage in Pseudomonas aeruginosa of algT and nadB: mutation in nadB does not affect NAD biosynthesis or alginate production.

Gene - 14 Apr 1995

DeVries C A, Hassett D J, Flynn J L, Ohman D E

Abstract excerpt

The 68-min region of the chromosome of Pseudomonas aeruginosa (Pa) contains the gene algT, encoding a putative alternate sigma factor similar to sigma E in Escherichia coli, that is required for the expression of several genes in the alginate biosynthetic regulon. Sequences immediately upstream from algT were found to contain a divergently expressed open reading frame encoding a 60-kDa protein with 64 and 36%...

Topics

Alginates
Amino Acid Oxidoreductases
Amino Acid Sequence
Bacterial Proteins
Base Sequence
Escherichia coli Proteins
Genes, Bacterial
Genetic Complementation Test
Genetic Linkage
Glucuronic Acid
Hexuronic Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Chemical

Molecular Sequence Data

Mutation

NAD

Niacin

Pseudomonas aeruginosa

Restriction Mapping

Source

Open in PubMed

Identifiers

PMID: 7737518
DOI: 10.1016/0378-1119(95)00028-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7737518-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genetic linkage in Pseudomonas aeruginosa of algT and nadB: mutation in nadB does not affect NAD biosynthesis or alginate production.PMID 7737518Read ↗

Pseudomonas aeruginosa AlgB, a two-component response regulator of the NtrC family, is required for algD transcriptionSemantic proximity Read ↗

The Azotobacter vinelandii alg8 and alg44 genes are essential for alginate synthesis and can be transcribed from an algD-independent promoter.Semantic proximity Read ↗

Pseudomonas aeruginosa AlgB, which modulates the expression of alginate, is a member of the NtrC subclass of prokaryotic regulators.Semantic proximity Read ↗

The gdhB gene of Pseudomonas aeruginosa encodes an arginine-inducible NAD(+)-dependent glutamate dehydrogenase which is subject to allosteric regulation.Semantic proximity Read ↗

DNA sequence and expression analysis of algP and algQ, components of the multigene system transcriptionally regulating mucoidy in Pseudomonas aeruginosa: algP contains multiple direct repeats.Semantic proximity Read ↗

Pseudomonas aeruginosa AlgZ, a ribbon-helix-helix DNA-binding protein, is essential for alginate synthesis and algD transcriptional activation.Semantic proximity Read ↗

Mucoid-to-nonmucoid conversion in alginate-producing Pseudomonas aeruginosa often results from spontaneous mutations in algT, encoding a putative alternate sigma factor, and shows evidence for autoregulation.Semantic proximity Read ↗

A mutation in algN permits trans activation of alginate production by algT in Pseudomonas species.Semantic proximity Read ↗

Identification of algF in the alginate biosynthetic gene cluster of Pseudomonas aeruginosa which is required for alginate acetylation.Semantic proximity Read ↗

Genetic analysis of the alginate biosynthetic gene cluster of <i>Pseudomonas aeruginosa</i> shows evidence of an operonic structureSemantic proximity Read ↗

The Pseudomonas aeruginosa homologs of hemC and hemD are linked to the gene encoding the regulator of mucoidy AlgR.Semantic proximity Read ↗

Characterization of the gene coding for GDP-mannose dehydrogenase (algD) from Azotobacter vinelandii.Semantic proximity Read ↗

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