Article
Molecular analysis of insulin receptor gene in Werner's syndrome.
Diabetes research and clinical practice - 31 Dec 1994
Uotani S, Yamaguchi Y, Yokota A, Yamasaki H, Takino H, Chikuba N, Goto Y, Fujishima N, Yano M, Matsumoto K
Abstract excerpt
Werner's syndrome is characterized by premature aging and frequent impaired glucose tolerance or overt diabetes. Insulin resistance may play an important role and may be caused by a post-receptor defect or dysfunctional insulin receptor. The present study was undertaken to investigate the insulin receptor gene mutation in Werner's syndrome. The genomic DNAs were obtained from four patients with Werner's syndrome....
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