Article
Molecular analysis of insulin receptor gene in Werner's syndrome.
Diabetes research and clinical practice - 31 Dec 1994
Uotani S, Yamaguchi Y, Yokota A, Yamasaki H, Takino H, Chikuba N, Goto Y, Fujishima N, Yano M, Matsumoto K
Abstract excerpt
Werner's syndrome is characterized by premature aging and frequent impaired glucose tolerance or overt diabetes. Insulin resistance may play an important role and may be caused by a post-receptor defect or dysfunctional insulin receptor. The present study was undertaken to investigate the insulin...
Topics
- Adult
- Amino Acid Sequence
- Aspartic Acid
- Base Sequence
- Exons
- Female
- Genetic Variation
- Humans
- Male
- Molecular Sequence Data
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptor, Insulin
- Werner Syndrome