Article
Forced expression of chimeric human fibroblast tropomyosin mutants affects cytokinesis.
The Journal of cell biology - 1 May 1995
Warren K S, Lin J L, McDermott J P, Lin J J
Abstract excerpt
Human fibroblasts generate at least eight tropomyosin (TM) isoforms (hTM1, hTM2, hTM3, hTM4, hTM5, hTM5a, hTM5b, and hTMsm alpha) from four distinct genes, and we have previously demonstrated that bacterially produced chimera hTM5/3 exhibits an unusually high affinity for actin filaments and a lo...
Topics
- Actin Cytoskeleton
- Actins
- Animals
- Blotting, Western
- CHO Cells
- Calmodulin-Binding Proteins
- Cell Division
- Cricetinae
- Fibroblasts
- Fluorescent Antibody Technique
- Giant Cells
- Humans
- Microscopy, Fluorescence
- Mutation
- Protein Binding
- Recombinant Fusion Proteins
- Species Specificity
- Structure-Activity Relationship