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Article

The essential transcription factor, Mcm1, is a downstream target of Sln1, a yeast "two-component" regulator.

The Journal of biological chemistry - 14 Apr 1995

Yu G, Deschenes R J, Fassler J S

Abstract excerpt

In a search for mutants exhibiting altered activity of the yeast transcription factor, Mcm1, we have identified the SLN1 gene, whose product is highly related to bacterial two-component sensor-regulator proteins. sln1 alleles identified in our screen increased Mcm1p-mediated transcriptional activation, while deletion of the SLN1 locus severely reduced Mcm1p activity. Our data establish that Mcm1p is a downstream...

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PMID: 7721779
DOI: 10.1074/jbc.270.15.8739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The essential transcription factor, Mcm1, is a downstream target of Sln1, a yeast "two-component" regulator.PMID 7721779Read ↗

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Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway.Semantic proximity Read ↗

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Isolation of CaSLN1 and CaNIK1, the genes for osmosensing histidine kinase homologues, from the pathogenic fungus Candida albicansSemantic proximity Read ↗

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The Saccharomyces cerevisiae MADS-box transcription factor Rlm1 is a target for the Mpk1 mitogen-activated protein kinase pathway.Semantic proximity Read ↗

Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor.Semantic proximity Read ↗

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