Article
High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype.
Archives of neurology - 1 Jul 1998
Galasko D, Chang L, Motter R, Clark C M, Kaye J, Knopman D, Thomas R, Kholodenko D, Schenk D, Lieberburg I, Miller B, Green R, Basherad R, Kertiles L, Boss M A, Seubert P
Abstract excerpt
OBJECTIVE: To evaluate cerebrospinal fluid (CSF) levels of amyloid beta protein ending at amino acid 42 (Abeta42) and tau as markers for Alzheimer disease (AD) and to determine whether clinical variables influence these levels. DESIGN: Cohort study. SETTING: Six academic research centers with exp...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoproteins E
- Biomarkers
- Dementia
- Diagnosis, Differential
- Female
- Genotype
- Humans
- Male
- Middle Aged