Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

On the origins of complex immune-mediated disease: the example of rheumatoid arthritis.

Journal of molecular medicine (Berlin, Germany) - 1 Apr 2009

Klareskog Lars, Wedrén Sara, Alfredsson Lars

Abstract excerpt

This essay discusses strategies for understanding the origins and outcomes of complex chronic inflammatory diseases using genetic and environmental determinants as tools for new definitions of disease subsets. Rheumatoid arthritis has been chosen as the prototype to illustrate these general concepts. Through recent data on two different disease subsets, it has been possible to devise a new molecular model for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to HLA-DR Antigens
Share to HLA-DRB1 Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune System Diseases

Share to Models, Biological

Share to Prognosis

Share to Risk Factors

Share to Smoking

Source

Identifiers

PMID: 19159118
DOI: 10.1007/s00109-008-0437-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

On the origins of complex immune-mediated disease: the example of rheumatoid arthritis.PMID 19159118Read ↗

The disease formerly known as rheumatoid arthritis.Semantic proximity Read ↗

Rheumatic diseases: environment and genetics.Semantic proximity Read ↗

The genetics of rheumatoid arthritis: risk and protection in different stages of the evolution of RA.Semantic proximity Read ↗

The etiology of rheumatoid arthritis.Semantic proximity Read ↗

Precipitating and perpetuating factors of rheumatoid arthritis immunopathology: linking the triad of genetic predisposition, environmental risk factors and autoimmunity to disease pathogenesis.Semantic proximity Read ↗

Genetics of rheumatoid arthritis: confronting complexity.Semantic proximity Read ↗

Rheumatoid arthritis in 2012: Progress in RA genetics, pathology and therapy.Semantic proximity Read ↗

One year in review 2017: pathogenesis of rheumatoid arthritis.Semantic proximity Read ↗

Rheumatoid arthritis, a complex multifactorial disease: On the way toward individualized medicineSemantic proximity Read ↗

Genetics, environment, and gene-environment interactions in the development of systemic rheumatic diseases.Semantic proximity Read ↗

Autoimmune Rheumatic Diseases — Problems of Immunopathology and Personalized TreatmentSemantic proximity Read ↗

One year in review 2020: pathogenesis of rheumatoid arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.