Amino acid 489 is encoded by a mutational "hot spot" on the beta 3 integrin chain: the CA/TU human platelet alloantigen system.

Article

Amino acid 489 is encoded by a mutational "hot spot" on the beta 3 integrin chain: the CA/TU human platelet alloantigen system.

Blood - 1 Dec 1993

Wang R, McFarland J G, Kekomaki R, Newman P J

Abstract excerpt

A new platelet alloantigen, termed CA, has recently been implicated in a case of neonatal alloimmune thrombocytopenia (NATP) in a Filipino family in Canada. Maternal anti-CA serum reacted with glycoprotein (GP) IIIa and maintained its reactivity after removal of high mannose carbohydrate residues...

Topics

Base Sequence
Blood Platelets
DNA, Complementary
Epitopes
Humans
Integrin beta3
Integrins
Isoantigens
Molecular Sequence Data
Mutation
Platelet Membrane Glycoproteins
Polymerase Chain Reaction
Polymorphism, Genetic

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