Hypersensitivity to oxygen is a uniform and secondary defect in Fanconi anemia cells.

doi:10.1016/0921-8777(93)90008-5

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Article

Hypersensitivity to oxygen is a uniform and secondary defect in Fanconi anemia cells.

Mutation research - 1 Oct 1993

Saito H, Hammond A T, Moses R E

Abstract excerpt

Cells from patients with Fanconi anemia (FA) frequently show an increased sensitivity to DNA crosslinking agents such as mitomycin C (MMC). FA cells also show abnormal sensitivity to oxygen tension. In order to examine the correlation between the two cellular defects in FA, several FA fibroblast lines were tested for their sensitivity to MMC and oxygen by colony-formation frequency. The sensitivity to MMC in...

Topics

Adolescent
Adult
Cell Division
Cell Line
Child
Child, Preschool
DNA
Fanconi Anemia
Female
Fibroblasts
Humans
Male
Mitomycin

Mutation

Oxygen

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