Hypermutation of the MYC gene in diffuse large cell lymphomas with translocations involving band 8q24.

Abstract excerpt

The sequence of the exon 1/intron 1 boundary region of the MYC gene was determined in two diffuse large cell lymphomas (DLCL), one with t(8;14) (q24;q32) and the other with t(8;22) (q24;q11). Both tumors had multiple mutations in this region. Also, both tumors had mutations in the protein binding site in intron 1, which is a frequent target for mutational inactivation in endemic Burkitt's lymphoma (eBL). The...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Base Sequence
• Share to Chromosomes, Human, Pair 8
• Share to Genes, myc