Article
Hypermutation of the MYC gene in diffuse large cell lymphomas with translocations involving band 8q24.
Genes, chromosomes & cancer - 1 Jul 1993
Bradley J F, Rothberg P G, Ladanyi M, Chaganti R S
Abstract excerpt
The sequence of the exon 1/intron 1 boundary region of the MYC gene was determined in two diffuse large cell lymphomas (DLCL), one with t(8;14) (q24;q32) and the other with t(8;22) (q24;q11). Both tumors had multiple mutations in this region. Also, both tumors had mutations in the protein binding...
Topics
- Base Sequence
- Chromosomes, Human, Pair 8
- Genes, myc
- Humans
- Lymphoma, Large B-Cell, Diffuse
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Translocation, Genetic