Article
Independent divergences in the CD4 binding site and V3 loop encoded in two seroprevalent Ugandan HIV-1 clinical isolates.
Journal of acquired immune deficiency syndromes - 1 Aug 1993
Pestano G, Prince A, Guyden J, Ntambi J M, Atkin A, Boto W M
Abstract excerpt
Two major epitopes expressed in HIV-1 have been recently shown to play a central role in virus neutralization. One of these important specificities is a type-specific or group-specific, principal neutralizing determinant (PND) located in the V3 loop of gp120. The other is a more broadly neutraliz...
Topics
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- CD4 Antigens
- Cloning, Molecular
- Cohort Studies
- Cross Reactions
- DNA, Viral
- Epitopes
- Genetic Variation
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Immune Sera
- Male
- Molecular Sequence Data
- Neutralization Tests